Rifampin, a CYP3A4 inducer, appreciably diminished the publicity to as well as pharmacodynamic outcomes of zolpidem. Use of Rifampin together with zolpidem may possibly decrease the efficacy of zolpidem.Coadministration of zolpidem with other CNS depressants increases the potential risk of CNS melancholy [see Warnings and Safeguards (5.two)]. Zolpi